Santhanam is a popular Tamil comedian and film actor in Tamil cinema. He has appeared in a whole range of films mostly as a friendly comedian. His fame started off in the television sitcom Lollu Sabha and popularity from the small screen level brought him to silver screen. He debuted in Manmadhan in 2004 and later appeared in several comedy and drama films. His acting style is very similar to the veteran comedian Goundamani.
Santhanam began his career in the popular comedy troupe Nungambakkam Boys Kondaatum who did comedy shows particularly during Diwali. The troupe included M. S. Bhaskar who occasionally assisted them with his performances. He moved to television shows such as Chinna Papa Periya Papa in 1999 and in Kovai Anuradha's Costly Maapillai. He became well known in a number of small time serials on STAR Vijay such as Ragalai vs. Sagalai and Lollu Sabha; the latter had turned Santhanam into a notable television personality.
He began acting in films, debuting in Manmathan alongside Silambarasan Rajendar and later acted with other stars in Sachein with Joseph Vijay, Sillunu Oru Kadhal with Surya Sivakumar, Something Something Unakkum Enakkum with Jayam Ravi, Rendu with R. Madhavan, Kireedam with Ajith Kumar and Kuselan with Rajinikanth. He played his only lead role in the 2006 comedy film Arai Enn 305-il Kadavul directed by Chimbudevan.
He resembles actor Goundamani in comedy style relying on sarcastic humour and abuse of his friends and his other associates.